… Polo-like kinases (PLKs) are marked by C-terminal polo box modules with critical protein
interaction and subcellular targeting roles… of a hidden set of polo boxes from the divergent PLK4…

… -terminal polo box domains that characterize PLKs are crucial … gained from PLK crystal
structures, evolution and interacting … view shows only the most frequently studied aspects of PLK …

… Plks, Plk4 contains three rather than two Polo box domains, and the function of its third Polo
box … of a phosphorylated species on SDS/PAGE and bound a similar amount of Slimb as WT-…

… Plk4s target mother centrioles through an interaction between their cryptic polo box (CPB)
and acidic … Polo boxes come out of the crypt: a new view of PLK function and evolution. …

… , PLKs contain a unique C terminal structure involved in Ser-pSer/pThr binding, called the
Polo box domain (PBD), comprising one or two polo boxes … Their PBDs contain two polo boxes …

… of known domains within specific taxonomical groups (eg the polo boxes of PLKs). … are
indicted in the grey boxes above the heat map (CR – conserved region; Crypt. – cryptic …

… and a C-terminal structure called the polo box domain (PBD) that is … view of the most frequently
studied aspects of PLK functions. … Polo Boxes Come out of the Crypt: A New View of PLK …

… The Polo-like kinases (PLKs) are a family of serine/threonine kinases that play a critical
role … region contains a single Polo-box and a central domain called the “cryptic Polo-box” (CPB). …

… 9 FIGURE 7: PLK functions and localizations in mammalian … In contrast, the PLK4 polo
box and its crypto polo box do not … motif, which is conserved all through evolution (Figure 8). …

… the first to describe and implement a concept of a stem cell as a … a polo-box domain (PBD)
which is a unique feature of the Plk … that our bodies developed evolutionary to silence the alien …